Publication

Genetic Clues to Postmenopausal Osteoporosis Risk

أغسطس 20, 2025

🧠 Introduction

Postmenopausal osteoporosis (PMOP) is a major public health concern, marked by a sharp decline in bone density and increased fracture risk among women. With growing evidence pointing to a genetic basis, a new systematic review explores which genetic markers may drive susceptibility to this condition.

🔍 Research Summary

This research analyzed data from a wide range of studies indexed in PubMed to identify genes most frequently linked to PMOP. Six genes emerged as major contributors, with the vitamin D receptor (VDR) gene leading the list. Others included TNFRSF11B, ESR1, COL1A1, MTHFR, and TGFβ1.

A meta-analysis revealed that specific variants—such as SNP rs1544410, rs11568820, and rs2228570 in the VDR gene, and the PvuII variant in the ESR1 gene—show statistically significant associations with increased or reduced PMOP risk. Together, these findings provide new insights into the genetic architecture of this widespread metabolic bone disease.

🌍 Broader Impact

By identifying genetic variants with potential predictive value, this study supports APMAD’s mission to advance precision medicine in metabolic disorders. These insights may help inform early detection strategies and personalized interventions for populations at higher risk. However, researchers emphasize the need for larger, ethnically diverse cohorts to validate these associations and translate them into clinical tools.

📎 Reference 

@article{Alhalwachi2025,
title = {Examining the association between genetic polymorphisms and osteoporosis among post-menopausal women: a systematic review},
journal = {Informatics in Medicine Unlocked},
volume = {56},
pages = {101652},
year = {2025},
issn = {2352-9148},
doi = {https://doi.org/10.1016/j.imu.2025.101652},
url = {https://www.sciencedirect.com/science/article/pii/S2352914825000401},
author = {Zainab Alhalwachi and Mira Mousa and Salsabeel Juneidi and Gabriela Restrepo-Rodas and Spyridon Karras and Habiba Alsafar and Fatme {Al Anouti}},
keywords = {Postmenopausal osteoporosis, Polymorphisms, Systematic review},
}

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