Dr. Faisal Alhosani, a recent PhD graduate from the University of Sharjah, led the study under the supervision of Prof. Rifat Hamoudi, in collaboration with Prof. Basel Al-Ramadi from the United Arab Emirates University. The work was carried out under the APMAD-ASPIRE VRI initiative, which fostered research collaboration between the two institutions.
The team focused on the gene CARD11, known to activate the NF-κB signaling pathway, a central mechanism in immune and inflammatory responses. Using transcriptomic profiling of colorectal cancer (CRC) cell lines and patient samples, the researchers investigated how CARD11 overexpression affects tumor biology. Notably, the study relied on formalin-fixed, paraffin-embedded (FFPE) tumor tissues — a technically challenging but clinically valuable data source — and applied advanced analysis methods to overcome known limitations.
Their analysis revealed that CARD11 overexpression contributes to cancer progression by promoting immune activation, inflammatory signaling, extracellular matrix remodeling, and enhanced chemotaxis. These findings not only shed light on a novel biomarker but also suggest new directions for targeted colorectal cancer therapies.
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