Exploring Histone Deacetylases in Type 2 Diabetes Mellitus

Our team has recently published a comprehensive review article titled “Exploring histone deacetylases in type 2 diabetes mellitus: pathophysiological insights and therapeutic avenues” in the journal Clinical Epigenetics.

Key Findings:

• • Histone deacetylases (HDACs) play a crucial role in various processes related to type 2 diabetes mellitus (T2DM), including pancreatic cell destiny, insulin release, and glucose metabolism.
  • HDACs also govern oxidative stress, inflammation, apoptosis, and fibrosis in T2DM.
  • HDAC inhibitors (HDACi) show promise as biomarkers and therapeutic targets for T2DM.

Implications

This review provides valuable insights into the role of HDACs in T2DM pathophysiology and highlights the potential of HDACi in improving insulin sensitivity, protecting β-cells, and reducing T2DM-associated complications.

About the Journal

Clinical Epigenetics is a peer-reviewed journal that focuses on epigenetic principles and mechanisms, as well as applications in clinical research and molecular diagnostics.